This Request for Proposals (RFP) provides grants for clinical repurposing trials led by researchers and clinicians based in low and lower-middle income countries (LMICs), as defined by the World Bank (https://data.worldbank.org/products/wdi-maps). This RFP is seeking clinical repurposing trials to address any unsolved disease facing patients in LMICs. However, CWR has a preference for trials that address high disease burden (https://ourworldindata.org/burden-of-disease) whether non-communicable diseases; communicable diseases; maternal, neonatal and nutritional diseases; or injuries.

Repurposed therapies must be approved and/or generally recognized as safe for human use by some regulatory agency, such as the US Food and Drug Administration, European Medicines Agency, Health Canada or Japan’s Pharmaceuticals and Medical Devices Agency, and can include generic drugs, nutraceuticals or indigenous therapies. These repurposed therapies must be tested in a new indication for which they are not already approved or used widely in clinical practice as standard of care. Repurposed therapies also may be added to current standard of care to improve patient outcomes and/or quality of life.

CWR is accepting budgets of up to US$65,000 for this funding opportunity. 

All submissions must include ideas and/or plans to engage the community of interest before, during and after the proposed clinical trial. CWR will provide up to US$7,500 in additional financial support for community engagement, with at least US$4,000 required for community engagement. 

CWR has a 2-stage submission process, starting with the brief Letter of Intent (LOI). The top-rated LOI submissions will be invited to submit a full scientific proposal. All submissions are ProposalCentral (https://proposalcentral.com). Search for “Cures Within Reach” and submit your proposal using the Repurposing Research in LMICs program. The LOI submission deadline is 11:59pm U.S. Eastern Time on March 28, 2025.