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REMEDi4ALL MULTI-STAKEHOLDER MEETING: Drug Repurposing, an Attractive Strategy in Pancreatic Cancer Treatment?
14 November 2023 @ 9:00 am - 5:30 pm
REMEDi4ALL is pleased to announce the first Multi-Stakeholder Meeting on drug repurposing in PANCREATIC CANCER.
This one-day in person workshop is aimed to bring together all relevant key stakeholders (patients and patient representatives, academia, industry, regulators, funders, etc.) to discuss the recent state of art on drug repurposing in oncology and specifically in pancreatic cancer. Topics of discussion will include an overview of the disease and the current (preclinical and clinical) drug repurposing programs, biomarkers, the importance of a patient-centred outcome measures and patient engagement activities in the study design and implementation. In addition, current hurdles including financial and regulatory barriers to successfully repurpose non-oncology drugs in pancreatic cancer will also be discussed.
Preliminary Agenda (might be subject to change)
| 8.30 – 9.00 | Welcome and Registration | ||
| 9.00 – 9.10 | Open Ceremony | Claudia Fuchs (REMEDi4ALL – EURORDIS) | |
| SESSION 1: SETTING THE SCENE
Moderator: Claudia Fuchs (REMEDi4ALL – EURORDIS) |
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| 9.10 – 9.30 | General Introduction on Pancreatic Cancer | Alfredo Carrato (Pancreatic Cancer Europe – PCE) | |
| 9.30 – 9.50 | Tackling pancreatic cancer: tricks and tips | Ilse Rooman (Anticancer Fund, Vrije Universiteit Brussels) | |
| 9.50 – 10.10 | Drug repurposing in oncology – Attractive but not that simple | Gauthier Bouche (REMEDi4ALL – Anticancer Fund) | |
| 10.10– 10.25 | REMEDi4ALL (vision, mission, European Context) | Donald Lo (REMEDi4ALL – EATRIS) | |
| 10.25 – 11.10 | Patient Perspective on Drug Repurposing in Oncology | Patrycja Rzadkowska (Pancreatic Cancer Europe – PCE and DiCE)
Ali Stunt (Pancreatic Cancer Europe – PCE and Pancreatic Cancer Action UK) |
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| COFFE BREAK 11.10 – 11.40 | |||
| SESSION 2: TREATMENT OPTIONS AND DRUG REPURPOSING OPPORTUNITIES IN PANCREATIC CANCER
Moderators: Gauthier Bouche/Patricia Vandamme (REMEDi4ALL – Anticancer Fund) |
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| 11.40 – 12.00 | Orphan Medicinal Products for the Treatment of Pancreatic Cancer: Lessons Learned From Two Decades of Orphan Designation | Violeta Stoyanova-Beninska (Medicines Evaluation Board, Chair of Committee for Orphan Medicinal Products at EMA) | |
| 12.00 – 12.20 | Preclinical and Clinical Updates on Drug Repurposing Opportunities in Pancreatic Cancer | Luca Cardone (Istituto Nazionale Tumori Regina Elena and National Research Council of Italy) | |
| 12.20– 12.40 | Patient Story | Steve Bigelsen (Rutgers New Jersey Medical School, Newark, NJ, USA) | |
| 12.40 – 13.00 | The VESPA Trial – Repurposing valproic acid combined with simvastatin to potentiate first line gemcitabine/nab-paclitxel-chemotherapy regimen in metastatic pancreatic cancer patients | Alfredo Budillon (REMEDi4ALL – Istituto Nazionale Tumori Fondazione Pascale)
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| LUNCH BREAK 13.00 – 14.00 | |||
| SESSION 3: THE PAST, PRESENT AND FUTURE OF PANCREATIC CANCER CLINICAL TRIALS
Moderators: Eve Hewitt/Rick Thompson (REMEDi4ALL- Beacon) |
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| 14.00 – 14.40 | Financial and Regulatory Barriers and Potential Solutions
– Overview on the current findings within REMEDi4ALL and future perspectives – Industry perspective – Funders persepective |
Heleen van der Meer (REMEDi4ALL – ZonMW)
Raluca Radu (REMEDi4ALL – Medicines for Europe) Hans Platteeuw (CEO Galenicap) Alexandre Bento Costa Alencar (Rising Tide Foundation) |
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| 14.40 – 15.00 | Biomarkers in Pancreatic Cancer | María Laura Garcia Bermejo (Ramon & Cajal Health Research Institute) | |
| 15.00 – 15.20 | Patient Centricity in Clinical Trials | Antonella Cardone (Cancer Patients Europe – CPE)
Federica Valsecchi (Fondazione Valsecchi) |
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| COFFE BREAK 15.20 – 15.50 | |||
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15.50 – 17.20 |
FINAL ROUNDTABLE AND DISCUSSION
Moderators: Claudia Fuchs (REMEDi4ALL – EURORDIS) – Rick Thompson (REMEDi4ALL – Beacon) |
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| 17.20 – 17.30 | Closing Remarks | Claudia Fuchs (REMEDi4ALL – EURORDIS)
Rick Thompson (REMEDi4ALL – Beacon) |
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| 17.30 | End of the Meeting and “GET TOGETHER” | ||
