Funding for Underresourced Researchers in Low and Lower-Middle Income Countries:
This Request for Proposals (RFP) from Cures Within Reach (CWR) is for the ReGRoW program, providing
grants for clinical repurposing trials led by underresourced researchers and clinicians based in low and
lower-middle income countries (LMICs), as defined by the World Bank (see
https://data.worldbank.org/products/wdi-maps) to impact LMIC-based patients. This RFP is seeking clinical
repurposing trials to address any unsolved disease facing patients in LMICs. CWR is interested in building
capacity for clinical research in LMICs while finding available and affordable treatments for patients in LMICs
through repurposing research.

While this RFP is accepting clinical repurposing trials addressing any unsolved disease, CWR has a preference
for trials that address high disease burden (see https://ourworldindata.org/burden-of-disease) whether
non-communicable diseases; communicable diseases; maternal, neonatal and nutritional diseases; or
injuries.

Repurposed therapies must be approved and/or generally recognized as safe for human use by some
regulatory agency, such as the US Food and Drug Administration, European Medicines Agency, Health
Canada or Japan’s Pharmaceuticals and Medical Devices Agency, and can include generic drugs, generic
devices, nutraceuticals or indigenous therapies. These repurposed therapies must be tested in a new
indication for which they are not already approved or used widely in the clinic as standard of care.

CWR is accepting budgets of up to US$65,000 for this funding opportunity (see Important Funding
Information below). Specific budget definitions for different types of costs can be found in the Letter of
Intent (LOI) submission instructions on ProposalCentral.

All submissions for this RFP are via CWR’s online grant management platform on ProposalCentral at
https://bit.ly/submittocwr using the Repurposing Research in LMICs program. Click on the “Apply Now”
button on the right to begin a submission. For more information about CWR’s funding opportunities
generally, visit https://bit.ly/cwrrfps.

CWR has a 2-stage submission process, starting with the LOI. Full scientific details are not required at the LOI stage. LOIs for this RFP will be reviewed, scored and ranked by CWR staff, external Grant Review Committee and/or Science Advisory Board members, and the top-rated LOI submissions will be invited to submit a full proposal as the second stage. Principal Investigators (PIs) will be contacted approximately 6-8 weeks following the LOI submission deadline with a decision.

The LOI submission deadline is 11:59pm U.S. Eastern Time on April 26, 2024. Contact Clare Thibodeaux,
PhD at clare@cureswithinreach.org with any questions.