UKRI Experimental medicine:
Apply for funding to investigate the causes, progression and treatment of human disease.

Your project must:

• include an experimental intervention or challenge in humans
• focus on a mechanistic hypothesis
• be academically-led

You must be based at an eligible research organisation.
There is no limit to the amount of funding you can apply for or the length of your project. We will fund 80% of your project’s full economic cost.

The following types of work are eligible for support:

• the use of novel readouts or technologies related to early evaluation of clinical efficacy or pathogenic mechanism
• the use of drugs, other interventions or measures with established safety profiles in new settings or conditions (for example, repurposing drugs as tool compounds to probe disease mechanism)
• characterisation or phenotyping of subjects using samples from clinical studies may be included where there is a clear link to a current treatment strategy but should not be the sole focus of your application:
  • limited, hypothesis-driven, retrospective sample analysis may be included at the start of the project to improve the design of the interventional, experimental medicine study
  • milestone criteria should clearly detail what data is required from the confirmatory analysis for the project to progress