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Drug repositioning/rescue (DR)

Finding a new use/indication for a (de-risked) drug molecule (i.e., drug substance for which human safety data are available). Generally, requires pharmaceutical product development (e.g., reformulation/dose adjustment), following redirection/bridging of an active drug development program, revival of an abandoned/shelved compound/off-market drug product, or a drug screening campaign to exploit alternative drug pathways/targets. May include drug combinations.