Cures Within Reach (CWR) is seeking collaborative, multisite clinical repurposing trials to address Meniere’s disease, as well as other related vertigo and hearing loss-related diagnoses, such as benign paroxysmal positional vertigo (BPPV), tinnitus, labyrinthitis and vestibular neuritis. CWR may also accept translational preclinical repurposing studies that can advance repurposed therapies to clinical trials or combination preclinical/clinical studies that produce robust data for publications, presentations, follow on funding and potential off label use. Submissions can come from accredited academic and nonprofit research institutions or health systems involved with medical research located anywhere in the world.

Repurposed therapies must be approved and/or generally recognized as safe for human use by some governmental regulatory agency and can include drugs, devices, nutraceuticals or combination therapies. These repurposed therapies must be tested in a new indication for which they are not already approved or used widely in clinical practice as standard of care. Repurposed therapies also may be added to current standard of care.

CWR is accepting budgets of up to $350,000 for collaborative, multisite clinical trials. CWR may also accept budgets up to $100,000 for translational preclinical studies. Submitted budgets must include the required institutional match. Contact CWR directly before submitting preclinical or combination preclinical/clinic studies to discuss fit and/or submission options.

Clinical trial designs should account for the high placebo effect found in Meniere’s disease research, and all studies should have an experimental design that allows for statistical analyses and data reproducibility.

CWR has a 2-stage submission process, starting with a Letter of Intent (LOI) followed by invitations to submit a full scientific proposal. All submissions for this RFP are via our online grant management platform on ProposalCentral (https://www.proposalcentral.com) using the Disease Specific Repurposing Research program. LOI submission deadline: 11:59pm U.S. Eastern Time on June 13, 2025.