Massimiliano Gaetani

Head of the Swedish National Unit of “Chemical Proteomics” - SciLifeLab

Massimiliano is the head of the Swedish National Unit of “Chemical Proteomics” of SciLifeLab and the Swedish national infrastructure for biological mass spectrometry (BioMS), and core facility at the Chemistry I Division of the Department of Medical Biochemistry and Biophysics of the Karolinska Institutet. Chemical Proteomics is a unique unit specialized in supporting projects with aims of drug target deconvolution and mechanism of action elucidation.

Massimiliano is a member of the management board of BioMS and of the management board of the Chemical Biology and Genome Engineering platform at SciLifeLab, nominated as SciLifeLab group leader since 2021. He has 20 years of experience in LC-MS and proteomics and expertise on several other areas of cell and protein analysis, including protein chemistry, thermodynamics, structural biology, biochemical and biophysical techniques. Massimiliano is inventor and developer of the PISA (Proteome Integral Solubility Alteration) assay and related integrative methods for proteome-wide target deconvolution and MoA elucidation, holding today the highest throughput, multiplexing, statistical power, and unique practicability on primary cells and precision medicine cell culture models.

Before his appointment at KI, he was: principal investigator, group leader, senior scientist and project manager at the University of Pittsburgh and Ri.MED Foundation of biomedical research; senior postdoc and manager of the protein thermodynamics platform at the San Raffaele Scientific Institute of Milan; research scientist and postdoc at the University of Pennsylvania and the Wistar Institute in Philadelphia (PA, US). 

Massimiliano Gaetani (MG) holds a M.Sc in Biotechnologies Summa cum Laude and a Ph.D. in Chemistry developed at the University of Pennsylvania and at The Wistar Institute (US). He also received international education by the Team Leadership and Management Course for PIs and Group Leaders, and the by the Executive Innovation Management Program at the Grenoble Business School.